Showing 68 results for Mic
Farideh Shishebor, Zahra Shamekhi, Majid Karandish, Seyed Mahmood Latifi,
Volume 1, Issue 2 (9-2011)
Abstract
Background & Objectives: There are limited number of studies conducted on the correlation between Glycemic index and Glycemic load of a food program and metabolic factors such as blood lipids in Asian countries including Iran. Therefore, this study aimed at analyzing the correlation between Glycemic index and Glycemic load of Iranian food program and blood lipids.
Materials & Methods: The subjects were 95 women working in Ahvaz University of Medical Sciences in the range of 20 to 55 years old. Glycemic index and Glycemic load of the food program was analyzed with 24-hour food recall questionnaires (4-6 recall). For calculating GI and GL, Iranian food GI tables, and also, international GI and GL table were used. The levels of blood lipids including HDL cholesterol, total cholesterol, and triglycerides of the blood were measured and the level of LDL Cholesterol was calculated using Friedewald formula. Also, Anthropometric measurements were done using standard methods.
Resulst: The mean age of subjects in this study was 36 years. GI mean was 72.1 and GL mean was 153.2. In this study, there was no significant relation between HDL cholesterol, LDL cholesterol, total cholesterol and Blood TG with Glycemic index and Glycemic load of food program. Conclusion: Unlike findings of west and Asian countries, both dietary GI and GL were not correlated with metabolic factors including blood lipid levels in this study , underreporting of individuals may influence the results of the study.
Noushin Sohrabi, Majid Tebianian, Heidarali Moeini,
Volume 1, Issue 2 (9-2011)
Abstract
Background & Objectives: Keratoconjunctivitis is considered as the most prevalent ocular disease which is caused by multiple microorganisms. Considering the fact that identifying etiologic agents of Keratoconjunctivitis in a specific geographical area, and determining their antibiotic resistance pattern could be very important in specifying treatment strategy of such patients, the present research has been conducted to discriminate and evaluate etiologic microbial agents of this disease in patients referred to ophthalmology ward of Feiz health center in Isfahan. Materials & Methods: This descriptive study has been conducted in an 18-month period on 196 patients, referred to ophthalmology ward of Feiz hospital with positive symptoms of Keratoconjunctivitis. Ocular secretions were sampled with sterile swap and from conjuctival sac. Then the related samples were transferred and cultured in the medium for bacteria. Antibiogram of isolated strains was performed by method of disc diffusion. One of the samples related to patients was transferred to virus transport media and was used for direct immunofluorescence test. The possible content of IgM anti-adenovirus was investigated by ELISA method and on serum samples of patients.
Resulst: From among the total 196 evaluated samples, 75 cases were infected with bacterial agents, 37 cases with adenovirus, and 58 cases with both bacterial and adenovirus agents. The isolated bacterial agents were as follows with respect to their prevalence, Staphylococcus aureus (28.1%), Coagulase negative Staphylococci (16.8%), Bacillus spp (6.6%), Pseudomonas aeruginosa (5.1 %), Enterobacter (4.2%), Klebsiella (3.6%) and Streptococcus group D (3.6%). From among antibiotic drugs, the highest rate of sensitivity for S. aureus and P. aeruginosa was observed in Ciprofloxacin and Tobramycin respectively.
Conclusion: The results of the study could be applied in specifying treatment strategies for patients suffering from Keratoconjunctivitis in Isfahan city.
Noushin Sohrabi, Majid Tebyanyan, Mehdi Mahdavi,
Volume 2, Issue 1 (5-2012)
Abstract
Background & Objective: Invasive Aspergillosis is a fatal infection in immunocompromised patients. The aim of this study was to evaluate the interaction of infectious with Aspergillus and tumor on immune response and cytokine network in Aspergillus infected tumor-bearing mice. Materials and Methods: Mice were implanted by sterile pieces of mouse mammary tumor and then infected by Aspergillus conidia by IV injection. Control groups mice were infected with Aspergillus conidia and/or implanted by sterile funga pieces of mouse mammary tumor. Seven days after Aspergillus infection, cytokine production of extracted splenocytes was analyzed by ELISA method.
Results: Tumor bearing mice which were infected with Aspergillus conidia showed remarkable increase in IL-4 production. Conversely, the levels of IFN-γ and IL-10 were decreased and TNF-α was increased moderately.
Conclution: Probably, Aspergillus infection could change cytokine production from CD4+ T helper cells and acquired immunity of tumor bearing mice. This point may be considered for better management of Aspergillus-infected patients suffering from cancer.
Vahid Hemayatkhah Jahromi, Hojatallah Karimi Jashni, Mozhdeh Mosallanezhad, Monireh Mosallanezhad, Hooshangh Jamali, Peyman Izadpanah,
Volume 2, Issue 1 (5-2012)
Abstract
Background & Objective: The vast use of microwave ovens in today's modern life and possible exposure of users to radiation exited from the oven lead us to investigate the effect of this radiation on sex hormones. In the present study, the effect of microwave ovens radiation leakage on concentration of LH, FSH and testosterone hormones has been investigated.
Materials & Methods: Thirteen immature two weeks- old male mice which weighing about 10 grams were used in this experimental study. Animals were randomly divided into 3 groups. Each group contained 10 mice. Experimental group 1 and 2 were exposed to microwave oven 30 and 90 minutes daily for 30 days, respectively. The control group received no radiation. Animals were anaesthetized and serum samples were stored. The concentration of testosterone, FSH and LH hormones were measured by RAI method.
Results: The serum testosterone levels showed significant decrease in experimental group 2. But levels of LH and FSH indicate no significant different in experimental group 1 and 2 when compared to control group.
Conclusion: Our results suggest that radiation leakage of microwave ovens might causes dysfunction in the levels of testosterone hormone secretion.
Hossein Ashraf , Reza Heydari, Vahid Nejati, Minoo Ilkhanipoor,
Volume 2, Issue 3 (11-2012)
Abstract
Background and Objective: Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal level is clinically very important. We decided to assess the preventive role of aqueous extract of Berberis Integerrima root on the serum levels of glucose, insulin, and lipid profile in Streptozotocin (STZ)-induced diabetic rats.
Materials and Methods: Forty male rats were divided into 5 groups as follows: 1- normal (N) 2- normal + barberry (N+B) (they received barberry root extract for 6 weeks) 3- diabetic (D) (they received STZ, 65 mg/kg BW /i.p.) 4- diabetic + barberry before (D+Bb) (they received barberry root extract for 3 weeks before STZ injection and continued for another three weeks) and 5- diabetic + barberry after (D+Ba) (three days after STZ injection, they received barberry root extract for 3 weeks). The experimental groups received barberry root extract (500 mg/kg bw) intra gastric by gavage for 6 weeks and the experimental period for each rat was 6 weeks.
Results: Diabetic rats showed a significant increase in serum glucose, total cholesterol, triglycerides, LDL-C, and food intake as well as a decrease in HDL-C, body weight and serum insulin, compared to the other groups. Administration of the barberry root extract in diabetic rats restored these changes towards normal to some extent.
Conclusion: In this study, for the first time, we showed that the administration of the barberry root extract before diabetes induction resulted in better amelioration in the serum levels of glucose, insulin, and lipid profile, compared to the group receiving it after induction: this indicates that the barberry root extract can play both a preventive and a therapeutic role in such patients.
Hamid Khosro Zamiri, Mehrdad Noroozi, Siavash Moradi, Mohammad Shabani , Ali Sharifi, Mohammad Ali Haghbin,
Volume 3, Issue 2 (9-2013)
Abstract
Background & Objective: The induction of anesthesia, laryngoscopy and endotracheal intubation can be associated with adverse hemodynamic response and increased intraocular pressure. The aim of this study was to evaluate intraocular pressure and hemodynamic changes after laryngoscopy and endotracheal intubation with three methods of laryngoscopy (Macintosh, Maccoy and Video laryngoscope).
Materials & Methods: One hundred and eighty patients with American Society of Anesthesiology (ASA) classification of I and II, aged 20-70 year, were enrolled in a randomized clinical trial (RCT). Anesthesia was induced by administration of Propofol 2 mg/kg, Fentanyl 1µg/kg and Cisatracurium 0.1mg/kg. the Hemodynamic information of the patients and intraocular pressures were documented and assessed in three stages (after induction of anesthesia and endotracheal intubation, and 5 minutes after endotracheal intubation using Maccoy, Macintosh and Video laryngoscope).
Results: Hemodynamic parameters' of patients increased in these three groups compared with those of pre anesthesia measures, but this increase was not significant. Evaluation of intraocular pressure (IOP) in Video laryngoscope group showed that there is a significant drop in intraocular pressure (IOP) compared with other groups. There weren’t any significant differences of IOP after intubation in Maccoy compared to the Macintosh group. Nevertheless there was not any significant difference in IOP, before and five minutes after intubation in these groups.
Conclusion: According to a low degree of augment of IOP in Video laryngoscope group and no changes in the Hemodynamic parameters, it seems that the use of Video laryngoscope in eye surgeries might be more suitable for endotracheal intubation.
Aziz Japoni, Mojtaba Anvarinejad, Shohre , Daviid Mehrbani, ,
Volume 3, Issue 4 (12-2013)
Abstract
Background & Objectives: Cyclophosphamide is an alkylating agent that stops the replication of DNA, which is used to treat various types of cancer and some autoimmune disorders. This study was aimed at then evaluating the immunomodulating effect of cyclophosphamide (Cy) on the immune system of vaccinated and non-vaccinated mice.
Materials & Methods: The study was performed on three groups of mice consisting of vaccinated, non-vaccinated and control groups. Vaccination was carried out by three separated courses of C. albicans injection intraperitoneally. Then, the vaccinated group received Cy on day zero and were challenged with lethal doses of C. albicans on days zero, one, 3, 6 and 12 post-Cy injection. Non-vaccinated group received Cy on day zero and similar to vaccinated ones were challenged with lethal doses of the organism. The control groups received just Cy on day zero and were sacrificed on days post-Cy injection. Then, the hemogram and the spleen and the renal tissues were studied microscopically and macroscopically.
Results: In the vaccinated group, an increase in survival time, the number of polymorphonuclear and the significant hyperplasia in the white pulp on days 6 and 12 post-Cy injection were noticed. In non-vaccinated ones, these factors had significant decrease on days 1 and 3.
Conclusion: It is concluded that the hyperplasia in the white pulp of spleen and an increasing in peripheral polymorphonuclear due to the selective effects of Cy could effectively protect the animal against C. albicans infection.
Mohammad Ali Haghbin, Hamid Khosro Zamiri, Marjan Shahabi, Mohammad Shabani, Hamed Vahdani,
Volume 4, Issue 2 (9-2014)
Abstract
Background &Objective: Plaryngoscopy and
tracheal intubation increase not only blood pressure and heart rate but also
Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and
during general anesthesia followed by mexiletine prescription .
Materials & Methods: In this study, 50
patients aged between 20 and 60 who were candidates for orthopedic surgery of
the upper limbs were surveyed. They were divided in two groups randomly. Two
hours before induction of anesthesia, case
and control groups received mexiletine 200 mg as capsule and oral placebo,
respectively. Systolic and diastolic blood pressures ,heart rate,
and BIS of both groups were compared before induction and intubation 1,3 and
10 minutes after intubation and immediately
, 15, 30, 45, and 60 minutes
after surgical incision.
Results: There was not any significant differences in systolic and
diastolic pressures of the two groups. The heart rate was lower in mexiletine group
compared to control group, 30 minutes after surgical incision and immediately
after extubation (P<0.05). BIS
was significantly more in mexiletine groupcompared to control group
(p<0/05).
Conclusion: It was revealed that
the hemodynamic changes after laryngoscopy and during general anesthesia
were significantly lower in mexiletine group compared to the control group. It`s suggested that the prescription
of this drug leads to the increase of BIS after intubation and during general
anesthesia.
Behrouz Moradhasel, Mostafa Taghipour, Masumeh Seidi, Vahab Dehlaghi, Sajad Pashotan Shayesteh,
Volume 4, Issue 2 (9-2014)
Abstract
Background
and Objective: Regulating body temperature
of premature infants and preparing them a desirable physical condition for
completing physical and mental development is essential. Using a system that
guarantees neonate’s health in incubator at first birth hours is cardinal.
Materials
and Methods: In this method, a set of non-contact infrared sensors
and microcontrollers regulate neonate’s body temperature without skin sensor.
Temperatures were converted to digital data after mean evaluation. They were
sent to digital microcontroller for user's settings and functional orders of
internal conversion system of incubator.
Results: In
this study, an intelligent system is presented for controlling body temperature
of premature infants in incubators without skin sensors.
Conclusion: This
technique causes incubator’s proper performance and safety. It prevents damages
to brain and other organs of premature neonates and reduces neurological
disorders of these infants.
Efate Alsadat Shojaei, Mehraban Falahati, Faride Zaini, Parivash Kord Bache, Parvaneh Rahimi Moghadam , Mohammad Reza Aghamirian, Shima Nozari, Ayesheh Makhdoomi , Sekhavatv Ameri, Sanam Afshar Moghadam ,
Volume 4, Issue 3 (11-2014)
Abstract
Background&
Objective: Candidal vulvovaginitis
occurs in female genital by the over growth of candida especially candida
albicans. This infection may be resistant to therapy and occasionally becomes
chronic. In some patients, this form of infection is recurrent. Moreover,
discovering new antifungal drugs and the use of these drugs in new methods
encourage mycologists to use these techniques. Therefore, according to the
above methods, this research investigated effects of several common antifungal
drugs with the use of combination methods against candida species isolated from
chronic candidal vulvovaginitis.
Materials&
Methods: This study carried out
on 19 strains of candida albicans that were isolated from recurrent
vulvovaginitis. The effects of clotrimazole, miconazole, fluconazole were
assessed separately and in combination with amphotericin B on candida albicans
using micro dilution methods.
Results: The mean Minimum Inhibitory Concentration (MIC)
of clotrimazole, miconazole, fluconazole, and amphotericin B were 7.05,
10.7,47, and 0.6 µgr/ml, respectively after 48 hours incubating. Then, the
azole antifungal drugs were evaluated in combination with amphotericin B. The
two combinations of fluconazole + amphotericin and miconazole + amphotericin
with the Fungicidal Inhibitory Concentrations (FIC) of 0.6 and 1, respectively,
attracted the most attentions. In addition, comparing the antifungal effects,
the most effective drug was amphotericin B with the Minimum Fungicidal
Concentration (MFC) of 1.18.
Conclusion: In this study, amphotericin B with the least
MIC had the best antifungal effect. The most and the least synergic effects of
combination therapy were for fluconazole + amphotericin B and Miconazole +
amphotericin B, respectively.
Shahrzad Nasisri Semnani , Mehdi Rahnema , Hasan Ghasempour , Hamed Alizadeh ,
Volume 4, Issue 3 (11-2014)
Abstract
Background & Objective: Staphylococcus aureus and Salmonella
typhimurium are among important causes of infection and antibiotic
resistance. It is essential to find antimicrobial compounds against them. The
objective of this study is to evaluate the antibacterial activity of Lecanora
muralis SP. extracts on Staphylococcus aureus and Salmonella
typhimurium in in-vitro and in animal model.
Materials & Methods: In this study, aquatic, acetonic, and ethanoic extracts of Lecanora
muralis SP. were prepared. Then their antimicrobial effects were
determined by agar well diffusion method. Minimum Inhibitory Concentration
(MIC) and Minimum Bacterial Concentration (MBC) were calculated by macro
dilution method. In animal model, 24 hours after inoculation of bacteria in
mice, care was provided by injecting 0.5 ml of Lecanora muralis SP.
extracts (as MBC concentration).. Then, the colonies of mentioned bacteria in
spleen were counted on agar media after nine days.
Results: The results indicated that MIC of acetonic extract of Lecanora
muralis SP. for Staphylococcus aureus and Salmonella typhimurium
were 103.75 and 207.5 mg/ml and for ethanoic extract were 49.81 and 99.625
mg/ml, respectively. The aquatic extracts of the tested lichens didn't show any
antibacterial activity on mentioned organisms. The mean of the bacterial count
in experiment group showed significant reduction compared to the control group
in animal model.
Conclusion: The ethanoic extract of Lecanora muralis SP.
had the most effective antimicrobial activity on Staphylococcus aureus
and Salmonella typhimurium in comparison with acetonic extract. In
addition Salmonella typhimurium was more sensitive to extracts.
Azam Moradi, Gholamhossein Ebrahimipour, Maryam Karkhane, Abdolrazagh Marzban,
Volume 4, Issue 4 (12-2014)
Abstract
Background
& Objective: In recent years, more
attention has been devoted to herbal medicines. Up to now, many compounds with
therapeutic effects has been extracted from the herbs. The aim of this study is
to evaluate the antioxidant and the antimicrobial effect of Rumex Alveollatus L. and to partially
identify the effective compounds in this plant.
Materials & Methods: Extraction was performed by using maceration method for
dried flower sample. Then, the antimicrobial effect of aqueous and ethanolic
extracts on eight bacterial sp. and two fungi were tested using disc diffusion
method. The antioxidant effect was also determined
through ferric reducing potency and phosphomolybdenum followed by total phenol
determination. Finally, partial detection of bioactive compounds was conducted
using chemical and calorimetric methods.
Results: The results showed that ethanolic extract had the most
antimicrobial effect while aqueous extract weakly affected bacterial and
fungal strains. Antioxidant experiments also revealed that ethanol extract had
more antioxidant effects than aqueous extract. The most content of total
phenolic compounds was found in ethanol extract. The results of the plant
chemical determination showed the presence of flavonoids, alkaloids,
anthraquinones, tannins, glycosides, and reducing sugars. Conclusion: Considering that few reports
about the therapeutic effect of Rumex alveollatus L. has been published, this
study could be considered as a valuable report about the important role of this
plant on preventing infections and neutralizing oxidant agents.
Sf Shaffiey, M Ahmadi, Sr Shaffiey, M Shapoori, H Varshoie, F Azari,
Volume 5, Issue 1 (4-2015)
Abstract
Background & Objective: CuO is one of the most important transition metal oxides due to its exclusive properties. It is used in various technological applications such as superconductors and gas sensors. Recently, it has been used as an antimicrobial agent against various bacterial species. In this study, we synthesized CuO nanoparticles and evaluated their antibacterial property.
Materials & Methods: Single crystalline nanoparticles of copper oxide having almost uniform particle size of 5-6 nm have been synthesized. The used technique is free from toxic solvents and amines, and it is based on a simple reaction of copper sulfate and De-ionized water (DI). In addition, their bactericidal effects against Aeromonas hydrophila ATCC 7966T bacteria were investigated. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined with well diffusion method and liquid culture for all of the Aeromonas hydrophila culture Medias.
Results: XRD(X Ray Diffraction) spectra confirmed the formation of single phase CuO nanoparticles. A minimum crystallite size of 5-6 nm was observed in the case of CuO nanoparticles. Transmission electron microscopy results corroborate well with XRD results. CuO nanoparticles exhibited inhibitory effects against Gram-negative bacteria.
Conclusion: The present study confirms that copper oxide nanoparticles have great ability as an antimicrobial agent against Aeromonas hydrophila.
Bagher Seyedalipour, Masumeh Oshrieh, Ramezan Khanbabaee,
Volume 5, Issue 1 (4-2015)
Abstract
Background & Objective: Zinc is an essential trace element which plays a key role in the growth and the development of the embryo during pregnancy. This study was designed to investigate the cytotoxic effects of zinc oxide nanoparticles on embryonic development and to assess the weight of body, kidney, and liver in Naval Medical Research Institute (NMRI) mice.
Materials & Methods: 25 female of NMRI mice weighting 30±3.0 gram were randomly divided into five groups (five in each group, four experimental groups and one control group). Mice in experimental groups one, two, three, and four received intraperitoneal ZnO nanoparticle with the concentrations of 50,100,150, and 200 mg / kg, respectively during 15 days (every other day). At the end, the weight of the body, the kidney, and the liver of the pregnant mice and the embryos were measured. In addition, histopathological evaluations were performed on embryos. The data were analyzed by SAS software in P≤0.05.
Results: Based on the macroscopic observations, the embryo and the kidney weights decreased and increased, respectively with increasing different concentrations of nanoparticle compared with controls (P≤0.05). Our data showed that at different concentrations of nanoparticles, the distance, the size, and the number of vertebral bodies increased compared to the control group. At the concentration of 150 mg/kg, an accumulation of mesenchymal cells for cartilage were observed and it seems that high dose of nanoparticles prevents embryo growth.
Conclusion: The results of this study indicate that ZnO nanoparticles cause embryonic developmental delay, undifferentiated and disorganized vertebral bodies in NMRI mice.
Abdorasoul Zakerin, Elaheh Ahmadi, Mehdi Fasihi-Ramandi, Sara Abdollahi, Alireza Molazadeh, Somayeh Jafari, Ghader Allahverdi, Seyed Amin Kouhpayeh, Mohammad Hasan Meshkibaf,
Volume 5, Issue 1 (4-2015)
Abstract
Background & Objectives: Ecologic conditions affect production of effective pharmaceutical products. We evaluate the effect of ecologic conditions on antibacterial effects of herbal plants in Fars.
Materials & Methods: We collected eight plant species including Trachyspermum copticum, Withania somnifera, Laurus nobilis, Carum carvi, Thymus, Rosemary, Zataria multiflora, and Lavandula in Fasa and Sepidan.. Their antibacterial effects were studied by disk diffusion method, well assay method, and Minimum Inhibitory Concentration (MIC). Ecological and weather conditions were derived from internet.
Results: Comparing with standard antibacterial indexes the following results were achieved. Fasa herbs including Trachyspermum copticum, Zataria multiflora, Laurus nobilis, and Rosemary had the most effect on Staphylococcus aureus, while Carum carvi had the least effect. This effect in Sepidan herbs was the most in Trachyspermum copticum, Zataria multiflora, and Rosemary, while Carum carvi had the least effect. Surveying the effects against E.coli among Fasa herbs, Zataria multiflora had the most and Carum carvi and Lavandula had the least effects. On the other hand, among Sepidan herbs, Trachyspermum had the highest and Carum carvi, Lavandula, and Laurus nobilis had the lowest effects on E.coli. Antibacterial effects of Fasa herbs against Pseudomonas aeruginosa was the most in Zataria multiflora and Thymus and the least in Carum carvi. In Sepidan herbs, it was the highest in Zataria multiflora and the lowest in Carum carvi.
Conclusion: Considering the differences in antibacterial effects of the herbs in two ecologic conditions, we suggest other researchers to pay attention to the mentioned effects in their studies.
Raziye Karimian, Nader Rahnama, Zeinab Karimimoghaddam, Maryam Karimian, Azam Janbozorgi,
Volume 5, Issue 2 (8-2015)
Abstract
Background & Objective: In order to reduce work-related musculoskeletal disorders in ergonomic approach, all effective factors in occurrence of disorders, should be evaluated. This approach can provide an optimal solution for the omission or reduction of work-related musculoskeletal disorders. The aim of the present study is ergonomic evaluation of nurses’ risk of suffering from musculoskeletal disorders with Quick Exposure Check(QEC) and the effect of 8-week selected corrective exercises and ergonomic occupational interventions on their exposure rate.
Materials & Methods: Therefore, Nordic questionnaire and Quick Exposure Check of the factor risk were applied for 6 tasks of nurses.
Results: 85.7% of nurses reported occupation as the major factor for musculoskeletal disorders and 89% of nurses’ tasks studied were in high or very high risk. There was a significant difference in care techniques used by nurses (P<0.05). Moving up patients (87.7%) had the highest risk and giving drugs (66.2%), determining the vein (65.1%), dressing a wound, participation in visiting patients (59.9%), and reporting (51.1%) were in the following risk orders. After 8 week corrective exercises and ergonomic interventions there was a significant reduction in the risk rate of suffering from musculoskeletal disorders in 6 tasks by nurses (P<0.05 ).
Conclusions: The results show that high risk level was a sign for susceptible conditions and workplaces in the hospital and corrective technique of moving up patients and improved conditions for moving up patients, improved other care techniques and selected corrective exercises reduced the risk level.
Atena Sadat Ghoreishi, Fahimeh Mohammadian Shahrbabaki, Navid Toghroli, Mahmoud Sheikh Fathollahi, Mohammad Reza Hajizadeh, Alireza Khoshdel, Mahdi Mahmoodi,
Volume 6, Issue 1 (3-2016)
Abstract
Background & Objectives: Diabetes is one of the most common diseases which is usually seen in modern societies. Due to the increased risk of the disease and its related complications, in addition to the harmless properties of sesame seeds, this research was aimed to study the effect of consuming sesame seeds on some biochemical factors in type 2 diabetic patients.
Materials & Methods: This clinical trial has been carried out on 60 type 2 diabetic patients who were randomly divided into two groups of 30 sesame seeds consumers (case) and 30 non sesame seeds consumers (control).The case group was given 60 grams sesame seeds per day for 2 months and the control group did not receive any sesame seeds. The patient information was collected by questionnaire. The fasting blood serum of patients at the beginning and the end of the testing were collected and the biochemical factors of this study were measured in laboratory. For the data analysis, two independent samples t-test and paired t-test were used.
Results: In this study, the mean ± SD (Standard Deviation) of the patients’ ages in the two groups, sesame seeds consumers (case) and non sesame seeds consumers (control), was 72/5 ± 40/52 and 11/6 ± 00/56 years, respectively. The results showed that fasting blood glucose, HbA1C, cholesterol, triglycerides, LDL (Low-density Lipoprotein), ALT (Alanine Transaminase) and ALP (Alkaline Phosphatase) were statistically decreased after the consumption of sesame seeds (P<0.05).
Conclusion: According to the results, and by considering the sesame seeds harmless effects, it can be suggested that probably this plant is useful as a complementary therapy for treatment and prevention of diabetes disorders.
Seyedeh Nasim Karimipour, Asghar Tanomand, Sadegh Rostamnia,
Volume 6, Issue 2 (8-2016)
Abstract
Background & Objective: Due to the high drug resistance in Acinetobacter baumannii, in this research, antibacterial properties of nano silver was evaluated for Acinetobacter baumannii.
Materials & Methods: The nano silver with approximate diameter of 20 nanometer from Pishtazan Inc. Mashad, Iran and 5 nanometer from the Department of Chemistry in Maragheh University were prepared. Its concentration was determined by spectroscopy method in Tabriz Chemistry University. Antimicrobial effects were determined by Mean Inhibitory Concentration (MIC) and Minimal Bacterial Concentration (MBC) by micro-broth-dilution method, disc diffusion and well diffusion methods. Anti-bacterial activity of nano-silver was tested for Acinetobacter baumannii NCTC12516 on 20 clinical strains (collected from Imam Reza Hospital in Tabriz).
Results: The results showed the MIC and MBC of 20nm nanoparticles were 1250 ppm and 2500 ppm, respectively. On the other hand, the MIC and MBC of 5 nm nanoparticles were 156 ppm and 312 ppm, respectively. According to these findings, the MIC and MBC identified for clinical Acinetobacter baumannii strains under study along with the NCTC12516 strain did not show a significant difference. Yet the amount of inhibition for the 20nm nanoparticles in the density of 20000 ppm of clinical Acinetobacter baumannii and NCTC12516 strains was 11 millimeter with the disc diffusion method and 9.5 millimeter for the well diffusion method with the same concentration. The amount of inhibition of 5nm nanoparticles in the 250-ppm concentration with both disc diffusion and well diffusion methods was 9.5 millimeter.
Conclusions: Acinetobacter baumannii is susceptible to nano-silver. Also the same MIC and MBC in multiple clinical strains suggests that there is not resistance to silver nanoparticles in Acinetobacter baumannii
Dr. Abolfazl Kamkar, Dr. Ali Khanjari, Ms. Mahbubeh Oladi, Dr. Ebrahim Molaee Aghaee,
Volume 7, Issue 1 (5-2017)
Abstract
Background & Objective: Herbal essential oils like Bunium persicum L. due to having anti-microbial and anti-oxidant properties, can be effective in prolongation of food shelf life. Considering environmental consequences arising from plastic packs, biodegradable covering films such as chitosan combined with herbal essential oils are an appropriate approach to controlling the chemical and microbial factors of food. This study aimed at investigating the anti-microbial and anti-oxidant effect of Bunium persicum L. essential oil combined with chitosan film on chicken meat packaging.
Materials & methods: Chitosan films were prepared with different percentage of Bunium persicum L. essential oil (0, 1 & 2%). Films were produced after homogenization and molding using casting method with glycerol (plasticizer) and tween 80 (emulsifier). Chemical and microbial tests were performed on days 0, 2, 4, 7 and 10 on chicken fillets without film (control) and those having different films, which were stored in°4 C. Statistical analysis was conducted using SPSS.
Results: Chicken samples packed with various films indicated lower values of chemical and microbial factors compared with control samples (p≤0.05) and generally a dose-response trend was observed by addition of essential oil.
Conclusion: Chicken meat packing with chitosan film, especially by adding different levels of Bunium persicum L. essential oil can play an inhibitory role in increasing effective factors related to chemical and microbial spoilage.
Dr Behnam Jedi-Behnia, Dr Saeid Abbasi Maleki, Dr Elahe Mousavi,
Volume 7, Issue 1 (5-2017)
Abstract
Background & Objective: Previous researches have revealed analgesic and sedative properties of Mentha spicata (MS). The aim of present study was to evaluate the antidepressant effects of MS essential oil in forced swim test (FST) and tail suspension test (TST) in male mice.
Materials & Methods: In this experimental study, 84 male mice were randomly divided into 14 groups of 6: Negative control groups received normal saline (10 ml/kg,i.p.), positive control groups received fluoxetine (20mg/kg, i.p.) and imipramine (30mg/kg) and treatment groups received MS essential oil (30, 60,120 and 240 mg/kg i.p.). In FST, immobility time, swimming time and climbing time and immobility time in TST were recorded in six minutes.
Results: Findings indicated that essential oil at doses of 120 and 240 mg/kg, fluoxetine and imipramine reduced immobility time compared to control group in FST and TST (p<0.001). Also, this essential oil and fluoxetine increased swimming time (p<0.001) without significant change of climbing time (p>0.05). In contrast, imipramine increased climbing time without any significant change in swimming time (p>0.05).
Conclusion: Based on the findings of the present study, MS essential oil has antidepressant-like activity similar to fluoxetine and probably their compounds (especially carvone) with serotonergic mechanism induced their effect. However, further studies are needed to determine the precise mechanism of its action.
