Showing 10 results for hajizade
Mahmood Karimy, Shamsedin Niknami, Aliraza Heidarnia, Ibrahim Hajizadeh,
Volume 1, Issue 3 (12-2011)
Abstract
Background & Objectives: When smoking is initiated at a young age, the risks of heavy smoking and nicotine dependence increases, Furthermore, among those with early onset of cigarette smoking, cessation would be more difficult. The purpose of this study was the assessment of health belief and patterns of cigarette smoking among adolescent students.
Materials & Methods: This research is an analytical and descriptive sectional study, carried out on 250 male students (15-19 years) of Zarandieh city high schools. Data collection was done by GYTS questionnaire which consist of twelve health belief question about cigarette smoking. Data analysis was performed using t-test and chi-square. P-value less than 0.05 were considered significant.
Results: The mean age of participants was 16.47 ± 1.13 years. The prevalence of cigarette smoking experience was 46% and water pipe use was 65%. The age of smoking onset was 12-15 years in 30.4% of the smokers. Among the smokers, 81% believed that smoking is harmful to health, 93.0% believed that they were able to quit smoking, 41% had tried to quit smoking. The significant differences between mean score of health beliefs about smoking among the smokers and nonsmokers were (p < 0.001).
Conclusions: The prevalence of smoking experience is high among Zarandieh adolescents. Therefore, it is necessary to develop more effective strategies for smoking prevention and cessation.
Saeid Bashirian, Alireza Haidarnia, Hamid Allahverdipour, Ebrahim Hajizadeh,
Volume 2, Issue 3 (11-2012)
Abstract
Background and Objective: Adolescence is the most critical period of life as regards commencing drug abuse. The social cost and damage caused by drug abuse in adolescence are enormous, necessitating interventional programs to prevent this behavior. The theory of planned behavior (TPB) is perhaps the most influential theory for the prediction of social and health behaviors such as drug abuse.
Materials and Methods: In this descriptive analytical study, samples were collected from male students in four high schools in different regions of Hamedan. The survey was carried out via random cluster sampling of 650 students. Data were collected using the standard self-report questionnaires and were analyzed using SPSS16, chi-squared test, correlation coefficient, and logistic regression analysis.
Results: Among the adolescents participating in this study, 11.1% had the experience of cigarette smoking, 3.4% had the experience of drug abuse, and 12% had the experience of intention to abuse drugs. There was a significant relationship between drug abuse and the following variables: smoking experience (p value =0.001, OR=27.238) having drug user parents (p value =0.001, OR=8.630) having friends who had experienced drug abuse (p value =0.001, OR=11.060) having best friends who had experienced drug abuse (p value = 0.001, OR=11.931) family with drug abuse (p value = 0.001, OR=4.311) and having a sibling who abused drugs (p value=0.001, OR=15.815). According to the logistic regression analysis, attitude, subjective norms, and perceived behavior control were the most influential predictors of intention to abuse drugs.
Conclusion: The use of TPB is beneficial in the predicting and planning for high-risk behaviors. TPB can be used for planning and implementing drug abuse prevention programs in adolescents.
Farzad Roshanzamir, Alireza Khoshdel, Mehdi Mahmoodi, Mohamadrezad Hajizade, Mohsen Rezaeian, Giti Farsi , Rezvan Bizhani, Mohamadmehi Naghizade,
Volume 4, Issue 1 (5-2014)
Abstract
Background & Objective: Obesity is one of the most important global health priorities as far as it increases illnesses and disorders the life quality. Alpha-1-Antitrypsin (AAT) is the most abundant serum protease inhibitor and prevents tissue degradation through proteases. Hence, its defect or deficiency significantly increases the risk of various diseases. AAT may be involved in the development and complications of obesity. The present study then was performed to determine the activity of AAT in the obese people compared to those with normal weight.
Materials & Methods: In this cross- sectional study, determining the AAT’s activity was performed through Trypsin-Inhibitor-Capacity (TIC) in healthy individual who were referred to the laboratory of Dr.Shariati in Fasa Hospital in April 2013.
Serum of 150 people with normal weight (Body Mass Index, BMI, ranges between 18.5 and 24.9) and the serum of 140 obese people (BMI more than 30) were surveyed. The data were analyzed by SPSS software using t-test and Pearson correlation coefficient.
Results: The serum amount of TIC in obese people (1.774±0.618 µmol/min/ml) was significantly lower than its amount in people with normal weight (3.047±0.498 µmol/min/ml) (P-value< 0.001). There was a significant negative correlation between TIC and weight (P< 0.001, R=-0.686). In addition, no significant correlation was observed between TIC and age sex and height.
Conclusion: The results showed that AAT in obese people was less in healthy individuals compared with the ones with normal weight. Therefore, it can be stated that AAT can be introduced as a clinical biomarker and be a potential target for treating obesity.
Saeedeh Jafarzadeh, Sima Mohamadkhan Kermanshahi, Ebrahim Hajizadeh,
Volume 4, Issue 4 (12-2014)
Abstract
Background & Objective:
Increase trend of overweight in recent years has become a concerning matter,
which is a health alarm for children. Therefore, the present study investigated
the impact of health promotion programs with collaborative approach on the
weight of overweight school age girls.
Materials & Methods: This quasi-experimental study was conducted in 2013, in which 80
overweight students in Firozabad were selected by non-randomized method and
were divided into case and control groups. The data collecting tools were
demographic information check list, electronic scale, and stadiometer. In the
case group, health promotion programs with three stages of assessment,
supportive planning, and evaluation was administered for three months.
Children’s weights in both groups were evaluated before and three months after
intervention. The results were analyzed by SPSS software version 16.
Results: Case and control groups
were equal from the view point of average weight before the intervention
(P>./05).While after intervention, "independent T test" showed a
significant different between two groups in average weight after intervention
(P<0/05). The paired T-test showed that the mean scores of weight for the
case group decreased from 48/95 to 47/39 after intervention (P<0/05).
However, the results showed that the mean scores of weight in the control group increased from 50/08 to
52/76 after study (P<0/05).
Conclusion: Health promotion programs with collaboration of children,
parents, and teachers could reduce the weight of overweight children.
Therefore, it is proposed for using this program in order to prevent overweight
and obesity in school age children.
Shirin Fattahpour, Farzaneh Hosseini, Mohammad Reza Hajizadeh, Mohammad Asadpour, , Gholam Hossein Hassanshahi, Mohammad Reza Mirzaii, Mehdi Mahmoodi,
Volume 5, Issue 1 (4-2015)
Abstract
Background & Objectives: Non enzymatic glycation is a reaction that occurs between reducing sugars and amino groups of proteins. Advanced Glycation End-products (AGE) have been accounted for principal biological processes like aging and pathogenesis of some diseases. Accumulation of AGE during hyperglycemia can cause structural and functional changes of long-lived proteins. Therefore, it will be effective to inhibit protein glycation formation in order to reduce or to improve diabetes complications. The aim of this study is to determine the effects of hydroalcoholic extract of Allium Hirtifolium on the formation of glycated hemoglobin.
Materials & Methods: In this experimental study, the effects of the various concentrations of 0.1, 0.3, and 0.5 gr/dl of hydroalcoholic extract of Allium Hirtifolium on the inhibition of hemoglobin glycation were examined. Hemoglobin A1c formation was assayed by ion exchange chromatography. The P-value < 0.05 was considered as the significant level.
Results: 10 and 14 days after incubation, at the concentration of 40 millimollar glucose, hemoglobin A1c formation decreased significantly by using 0.5 gr/dl of hydroalcoholic extract of Allium Hirtifolium.
Conclusion: The results revealed that Allium Hirtifolium can inhibit hemoglobin A1c formation in hyperglycemic condition. Therefore, it is suggested that Allium Hirtifolium can be useful for preventing the complications of diabetes.
Fahime Mohamadian, Mehdi Mahmoodi, Mohamadreza Mirzae, Alireza Khoshdel, Mahmood Sheikh Fathollahi, Nahid Zeinodini, Mohamad Reza Hajizade,
Volume 5, Issue 3 (11-2015)
Abstract
Background & Objectives: Breast cancer is one of the most common cancers among women. Incorrect pattern of gene expression involved in epigenetic including APOBEC3B, DNMT-1, and TET-1 can develop breast cancer. Quercetin is a natural flavonoid with antioxidant and anti-cancer properties that have been reported in other studies. To investigate the effect mechanism of quercetin, this study examined the effect of quercetin on the expression of genes which were referred to in two classes of breast cancer cell lines.
Materials & Methods: Cell lines including MCF-7 and MDA-MB-453 in separate boxes in the control group and the treated groups with two dosages of 50 and 100 mm of quercetin were cultured for 24 and 48 hours, respectively. RNA was extracted from the cells and then was converted to cDNA. Real-time PCR was used for APOBEC3B, DNMT_1, and TET-1 expression.
Results: The results showed that quercetin had conflicting results after 24 hours in two cell lines as there was a decrease in the gene expression of APQBEC3B and an increase in that of DNMT-1 in MCF-7 cell line. In contrast, the cell line of MDA-MB-453, APOBEC3B, and DNMT-1 gene expression increased. While the 48-hour results showed that quercetin reduced the gene expression of APOBEC3B and DNMT-1 and increased that of the TET-1 in both cell lines.
Conclusion: Due to the satisfactory effects of quercetin on breast cancer cells after 48 hours, these effects can be probably applied through epigenetic mechanisms. However, the final decision needs further investigation.
Hadis Ahmadiraad, Mina Hemmati, Mehdi Mahmodi, Ahmadreza Sayadi Anari, Mohammadreza Mirzaee, Alireza Khoshdel, Maryam Amiri, Fahimmeh Mohammadainshahrbabaki, Mohammadreza Hajizade,
Volume 5, Issue 4 (12-2015)
Abstract
Background & Objectives: Industrial pollution including trace elements is the ability to exert many biological effects such as cancer and inflammatory diseases on humans. Therefore, in this study, some of the inflammation and cancer awareness factors such as P53 and IL6 and some blood indices are examined along with trace elements to which people are normally exposed.
Materials & Methods: The population includes 45 workers subjected to trace elements who are studied in comparison with the control group with some biochemical parameters such as WBC, RBC, and CRP. In addition, gene expressions of p53 and IL6 are measured by Real time PCR technique.
Results: The results show that the gene expressions of IL6 and P53 increases significantly (P –Value p53=0.00, IL6=0.0037). Furthermore, the number of red and white blood cells demonstrate a substantial upsurge. The level of liver enzymes of ALT and AST grows. Additionally, ALP reduces and CRP is negative in all the subjects. (P = 0.001).
Conclusion: The results confirm that industrial pollution is able to induce some changes in gene expressions of P53, IL6, and some blood parameters. It may create serious risks for people who will be exposed to pollution in the future.
Atena Sadat Ghoreishi, Fahimeh Mohammadian Shahrbabaki, Navid Toghroli, Mahmoud Sheikh Fathollahi, Mohammad Reza Hajizadeh, Alireza Khoshdel, Mahdi Mahmoodi,
Volume 6, Issue 1 (3-2016)
Abstract
Background & Objectives: Diabetes is one of the most common diseases which is usually seen in modern societies. Due to the increased risk of the disease and its related complications, in addition to the harmless properties of sesame seeds, this research was aimed to study the effect of consuming sesame seeds on some biochemical factors in type 2 diabetic patients.
Materials & Methods: This clinical trial has been carried out on 60 type 2 diabetic patients who were randomly divided into two groups of 30 sesame seeds consumers (case) and 30 non sesame seeds consumers (control).The case group was given 60 grams sesame seeds per day for 2 months and the control group did not receive any sesame seeds. The patient information was collected by questionnaire. The fasting blood serum of patients at the beginning and the end of the testing were collected and the biochemical factors of this study were measured in laboratory. For the data analysis, two independent samples t-test and paired t-test were used.
Results: In this study, the mean ± SD (Standard Deviation) of the patients’ ages in the two groups, sesame seeds consumers (case) and non sesame seeds consumers (control), was 72/5 ± 40/52 and 11/6 ± 00/56 years, respectively. The results showed that fasting blood glucose, HbA1C, cholesterol, triglycerides, LDL (Low-density Lipoprotein), ALT (Alanine Transaminase) and ALP (Alkaline Phosphatase) were statistically decreased after the consumption of sesame seeds (P<0.05).
Conclusion: According to the results, and by considering the sesame seeds harmless effects, it can be suggested that probably this plant is useful as a complementary therapy for treatment and prevention of diabetes disorders.
Hossein Mohammadpour, Vahid Razban, Dr Mahdi Mahmoodi, Mohammad Reza Hajizadeh, Maryam Hosseinipour, Atena Sadat Ghoreishi, Gity Farsi, Farzaneh Sadat Hosseini, Ali Reza Khoshdel,
Volume 7, Issue 2 (9-2017)
Abstract
Background & Objectives: Adipose-derived stem cells (ADSCs) have been investigated as a promising cell source for therapeutic and engineering applications. Common proliferation protocols use fetal bovine serum (FBS) as a growth factor which is potentially a source of pathogens, and contains animal antigens that can cause an allergic reaction after transplantation in the recipient, and regarding immunity, human serum (HS) could be a suitable alternative to it. The aim of this study is to compare the culture medium enriched with FBS or HS as supplements in the proliferation and differentiation of ADSCs.
Materials & Methods: Human serum was extracted from 90 ml venous blood of a healthy person, taken in respective intervals. The ADSCs were isolated according to the protocol from adipose tissue after lipolysis operation and cultured by mediums enriched with FBS or HS. Expression of the surface markers of ADSCs was investigated by flow cytometry. Osteogenic differentiation was evaluated by Alizarin Red staining method.
Results: The analysis of cell growth showed that the isolation and proliferation of ADSCs in both media (HS & FBS) were similar, but there was a significant difference in case of differentiation in the HS medium.
Conclusion: This study showed that FBS could be replaced by HS in case of isolation, proliferation and differentiation of stem cells studies as supplement. Furthermore, our data suggest a fast and safe proliferation protocol by using human serum in the stem cells culture and cell-based therapies.
Farzad Roostaee, Shima Zanganeh, Mohammad Reza Shafiepour, Mehdi Mahmoudi, Alireza Khoshdel, Mohammad Reza Hajizadeh,
Volume 8, Issue 4 (12-2018)
Abstract
Background &Objective: Resistin is an adipokin secreted from adipose tissue and immunity cells. Relationship between resistin and metabolic syndrome and its components is controversial. The aim of this study is measurement of serum resistin level, insulin resistance and other factors in subjects with and without metabolic syndrome.
Materials & Methods: this cross-sectional study was conducted in 2015, 56 availableperson including; 31subjects were enrolled as the study group and 25 subjects were recruited as the control group of the study. Serum resistin concentrations were measured by ELISA and its association with metabolic syndrome markers was measured. Data were Analyzed using independent T test, Pearson correlation Test and, Chi-squared Test
Results: Serum resistin levels were significantly higher in the metabolic syndrome subject compared with control group (p-value=0.002). Correlation analysis revealed body mass index (p=0.018; r=0.480), waist circumference (p=0.015; r=0.431), systolic blood pressure (p=0.008; r=0.467), diastolic blood pressure (p=0.001; r=0.562), cholesterol (p=0.018; r=0.421) and LDL (p=0.003; r=0.515) were positively correlated with plasma resistin.
Conclusion: Serum resistin levels are elevated in subjects with metabolic syndrome and are associated with some of its components in metabolic syndrome patients, resistin may be associated with the severity of this syndrome and its complications.
