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The Effect of Storage Longtime on Cyanide Production in Postmortem Stored Tissues
Saeeid Gholamzadeh, Maryam Akhghari, Mohammad Zarenezhad, Jaber Gharedaghi, Mahmoud Montazeri, Alireza Doroodchi, Bahare Kazemi,
Volume 6, Issue 4 (12-2016)
Abstract

Background & Objective: Acute cyanide poisoning happens intentionally as suicide attempt or in accidental use. Interpretation of cyanide analysis results in postmortem samples is important in forensic medicine.

Material & Methods: In this case-control study, the liver and the lung of 100 autopsy cases were collected during six months in Shiraz Forensic Medicine Department. Samples were divided into three parts and were examined as follow: one part of the liver and the lung was analyzed qualitatively to detect cyanide with Prussian blue test at first day of admission, the second and the third parts of the samples were stored at 0-4°C for one and two months, respectively. Then, liver and lung samples were analyzed to measure the amount of cyanide.

Results: Cyanide was detected in only six cases in all three parts of the liver samples. Screening results for cyanide were negative for the remaining 94 liver samples.

Conclusion: Endogenous cyanide production was not detected in liver and lung samples in this study. Therefore, cyanide detection was not affected by the time of the storage of the samples. The cyanide level changes in mentioned tissues were not significant. More importantly, our results would be more advantageous if we studied quantitatively on more samples to pave the way for future studies.


Antimicrobial Activity and Wound Healing Properties of Aloe Arborescens Extract: An in Vivo Study
Fatemeh Ghane, Pegah Rasouli, Benafshe Khanjari, Alireza Yousofi, Ali Zarenezhad, Hossein Fattahi, Mahsa Rostami Chaijan, Abdolmajid Ghasemian , Behnoosh Miladpour , Elham Zarenezhad,
Volume 13, Issue 2 (5-2023)
Abstract
Background & Objective: Burn is one of the prominent causes of death around the world, however drug discovery attempts for burn healing has not been entirely successful. Aloe arborescens (A. arborescens), is effective in the burning wounds healing and growth inhibition of bacterial pathogens. Our objective was to assess the wound healing and antibacterial effects of A. arborescens in vivo.
Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for 21 days and sampling was conducted on days 14 and 21 and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method.
Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Gram-positive (Staphylococcus aureus, Bacillus cereus) bacterial species.
Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.
 

A Complementary Therapy with Trigonella foenum-graecum L. and Citrullus colocynthis (L.) in Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Clinical Trial
Babak Pezeshki, Seyed Mohammadreza Torabi, Massih Sedigh Rahimabadi, Hossein Pourmontaseri, Foroogh Namjoyan, Mohammad Hossein Dabbaghmanesh, Elham Zarenezhad, Mehdi Sharafi, Dr Mahsa Rostami Chijan,
Volume 14, Issue 2 (3-2024)
Abstract
Background & Objectives: Diabetes is a known chronic disease affecting more than 400 million people and causing millions of deaths worldwide annually. The World Health Organization predicts that by 2030, diabetes will become the seventh leading cause of death. In the last decades, numerous chemotherapy approaches have been used. However, herbal remedies have accounted for more than 70 percent of the total administered antidiabetic treatments during the last decade. In this study, we aimed to develop a novel natural antidiabetic therapy with Trigonella foenum-graecum (T. foenum-graecum) L. and Citrullus colocynthis (C. colocynthis) (L.). Based on past studies, using C. colocynthis singly can cause diarrhea, abdominal pain, and heartburn, hence in order to reduce these complications, we applied this plant in combination with T. foenum-graecum based on the recommendations of Persian medicine references.
Materials & Methods: We admitted 34 diabetics aged 30-65 years old to design a double-blind parallel randomized controlled clinical trial. We prepared therapeutic capsules containing a combination of 40 mg of C. colocynthis and 350 mg of T. foenum-graecum L. We divided participants into an interventional (n=17) and placebo (n=17) groups and measured fasting blood sugar (FBS) levels, lipid profile, and liver function tests initially. After two weeks, all participants returned for a visit, and FBS and blood sugar (BS) were measured. At the end (12th week), all outcomes were measured and analyzed using an independent t-test and Chi-squared (χ2).
Results: The FBS levels decreased significantly in the intervention group compared to that of the control group (171.8±54.9 versus 149.6±46.4, p=0.024), but the improvements in the lipid profile and liver function were not statistically significant.
Conclusion: This study unveiled that combination of T. foenum-graecum L. and C. colocynthis L. at safe levels significantly decreased the FBS levels among T2DM patients. Further studies are needed to provide more efficient antidiabetic effects with the low side effects.

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