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The Effect of Interaction of Hydroalcoholic Extract of Ginger Rhizome (Zingiber Officinale) with Nitric Oxide System on Mechanical Activity of Isolated Trachea of Male Rats
Fereshteh Dadfar , Aminollah Bahaoddini , Seyyed Ebrahim Hoseini ,
Volume 4, Issue 1 (5-2014)
Abstract
Background &Objectives: Ginger is a plant that was used for bronchodilation from the ancient times. The aim of this study was to evaluate the effect of hydroalcoholic extract of Zingiberofficinale on mechanical activity of isolated trachea and its interaction with nitric oxide system. Materials & Methods: 15 adult male rats after adapting with their environment for one week were anesthetized with intraperitoneal injection of sodium pentobarbital and theirs trachea were isolated and divided into 3-mm strips. Then the isolated tracheal strips were divided into control and experimental groups that were inserted to organ bath contained krebs solution. The mechanical activity of trachea was recorded by power lab system. After establishing the basic conditions, in experimental group, hydroalcoholic extract of ginger (0.3mg/ml) and to control group in the same conditions, ethanol 70% as solvent was added. Then, mechanical activity of each group in the presence of L-NAME was recorded. The data were analyzed through paired sample t- test at P ≤ 0.05 as the significant level. Results: The results showed significant decrease of mechanical activity of tracheal strips in the group which was exposed to ginger. These effects were not reversed after administration of L- NAME in comparison with the control group. Conclusion: It can be concluded that ginger has an inhibitory effect on mechanical activity of trachea which is probably independent from nitric oxide system.
The effect of gold, silver and zinc oxide nanoparticles on oxidative stress parameters level in the liver, heart and lung of male mice
Kourosh Bamdad, Bagher Mohammadgani, Fereshteh Dadfar, Ali Moradi,
Volume 7, Issue 4 (12-2017)
Abstract 
Background & Objective: Nowadays, the beneficial effects of nanomaterials are accepted in medicine and industry. Considering the increasing use of nanoparticles and their possible toxicity, the effect of nanoparticles on oxidative stress markers was investigated in this study.
Material & Methods: In this experimental- interventional study, 32 Balb mice were divided into 4 groups of 8. The control group received saline, and other three groups received gold, silver, and zinc oxide nanoparticles at a concentration of 100 PPM with IP injection during 28 days. After anesthesia, the tissues of liver, heart and lung were removed, and the activity level of oxidative stress markers was evaluated.
Results: MDA level was significantly increased in zinc oxide treatment group in all three tissues and in gold treatment group in liver tissue. This factor showed a significant decrease in silver nanoparticle treatment in these tissues. The activity of catalase and glutathione peroxidase enzymes in the treatment of silver nanoparticle showed a significant increase. While in the treatment group with zinc oxide and gold nanoparticles, the activity of these enzymes decreased, this decrease was significant only in zinc oxide nanoparticle.
Conclusion: It is concluded that the silver nanoparticle acts as a useful nanoparticle by decreasing MDA and oxidative stress and inducing antioxidant enzymes, while the effect of zinc oxide nanoparticle shows its toxicity.
 

The Effects of Hydroalcoholic Extract of Thyme (Zataria multiflora Boiss.) on Mechanical Activity of Isolated Colon of Male Rat
Aminollah Bahaoddini, Fereshteh ِِdadfar, Mohhamad Ahmadipour,
Volume 11, Issue 1 (3-2021)
Abstract
Background & Objective: Thyme have been used as a medicinal plant traditionally for the treatment of digestive system disorders. In present study, the effect of hydroalcoholic extract of thyme on motility of isolated colon of male rat and its interaction with cholinergic, adrenergic and nitic oxide systems was performed.
 Materials & Methods: Ten adult male rats (180- 250 g) were kept in standard condition for one week. Then rats were anaesthetized by ethyl ether and their colon was isolated and divided in to 1 cm strips. The strips were held to a force transducer and inserted to organ bath contained Tyrode solution. The mechanical activity of strips was recorded by Power Lab system with administration of thyme extract (0.0175 mg/ml) and its solvent in experimental and sham groups, and after administration of acetylcholine, epinephrine and L-NAME drugs. Data were analyzed by SPSS software and independent-samples T-test.
 Results: The result showed a significant decrease in the mechanical activity of isolated colon after administration of the effective dose of thyme extract in base line and after of administration of acetylcholine.
There was no significant difference of mechanical activity of the strips at the presence of extract and its solvent after epinephrine and L-NAME administration.
Conclusion: It can be concluded that thyme extract caused colon relaxation via inhibition of cholinergic pathway and independent from adrenergic and nitric oxide systems.

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