:: Volume 6, Issue 2 (Summer 2016) ::
JABS 2016, 6(2): 155-161 Back to browse issues page
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats
Leila Hejazi1, Seyed Ebrahim Hosseini2
1- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran , ebrahim.hossini@yahoo.com
Abstract:   (9349 Views)

Background & Objective: Gelofen is one of the anti-inflammatory drugs which is used to relieve the pain and reduce the inflammations. This drug has side effects on body's tissues. This study aimed to investigate the effect of Tribulus terrestris (Tt) plant on hepatic transaminases due to the Gelofen consumption.

Materials & Methods: In this experimental study 56 rats were divided into 7 groups of 8 rats, including control, sham and 4 experimental groups receiving Gelofen 400mg / kg, Tt extract 80 mg / kg, Tt extract 20mg / kg and Gelofen with 400mg / kg doses, Tt extract  40mg / kg  and Gelofen 400mg / kg, and Tt extract 80mg / kg  and Gelofen 400mg / kg. Gelofen was prescribed intraperitoneal and Tt was prescribed orally for 21 days. At the end of phlebotomizing the animals, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Anaplastic lymphoma kinase (ALK) levels were measured, and the results were analyzed by ANOVA and Duncan tests. The significant difference in the data was considered P> 0/05.

Results: The results showed that the transaminase concentration in the groups receiving Gelofen alone and with the Tt extract in doses of 20mg /kg and 40 mg /kg had a significant increase compared to the control group and the groups receiving Tt alone and Tt with the dose of 80mg/kg with Gelofen,had a significant decrease compared to the control and Gelofen alone groups (P> 0/05).

 Conclusion: The results showed that the Tt extract led to prevent the negative effects of Gelofen on hepatic tissue in a dose-dependent manner and in result on the serum levels of liver transaminases.

Keywords: Gelofen, Tribulus terrestris, ALT, AST, ALK, Rat
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Type of Study: Research | Subject: Physiology
Received: 2015/10/17 | Accepted: 2016/01/30 | Published: 2016/09/10

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Volume 6, Issue 2 (Summer 2016) Back to browse issues page