:: Volume 4, Issue 1 (Spring 2014) ::
JABS 2014, 4(1): 50-57 Back to browse issues page
Comparison of IgG and IgA Antibodies Titrations against Helicobacter Pylori in Urban and Rural Populations in Mazandaran Province
Mina Owrang1, Isa Tahmasbpour Marzony2, Saber Imani3, Heshmat Darzy4, Amir Nejadmoghadam5
1- Department of Biology, Islamic Azad University, Sari Branch, Sari, Iran. , mina.orang@gmail.com
2- Member of Young Research Club, Islamic Azad University, Sari Branch, Sari, Iran.
3- Young Elite and Researcher Clubs, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
4- Laboratory Science, Centre of Pathology, Sari, Iran.
5- Chemical Injuries Research Center, Baqiyatallah Medical Sciences University, Tehran, Iran.
Abstract:   (17208 Views)

Background & objective: The infection caused by Helicobacter pylori (H. pylori) is one of the most common bacterial gastrointestinal diseases throughout the world. Based on the role of H. pylori in a variety of diseases such as gastrointestinal and lymphoma, present study is aimed to consider the concentration of IgA and IgG against H. pylori in both rural and urban populations and then its relationship with some demographic characteristics.

Materials & Methods: In this descriptive study, 400 sera samples were collected from both genders at the Sari treatment- health center. After blood collection, the concentration of IgG and IgA against H. pylori was measured by ELISA kit.

Results: There was no significant difference in antibodies titration between men and women. Approximately 18.5% of males and 16.5% of females were positive regarding to IgA and 70.2% of men and 66.7% of women were positive regarding to IgG. The mean of antibodies in rural populations (0.87±0.35) was significantly (p<0.001) higher than those in urban populations (0.78±0.41). The mean of antibodies in patients who had a history of gastrointestinal infection was significantly higher than others (p<0.05).

Conclusion: Due to the high level of IgA and IgG antibodies in studied populations, especially in rural people, and lack of symptoms in patients, the screen of positive serologic populations can be helpful for the management and control of infections caused by H. pylori.

Keywords: IgA, IgG, Helicobacter pylori, Rural and Urban Populations
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Type of Study: Review | Subject: Developmental Biology
Received: 2014/06/11 | Accepted: 2014/06/11 | Published: 2014/06/11

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