Volume 7, Issue 3 (11-2017)                   JABS 2017, 7(3): 377-389 | Back to browse issues page

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Hatami S, Hatami H, Sheikhzade F, Dehgan G. Pretreatment of alcoholic extract of Scrophularia Striata on spatial memory and lipid peroxidation in male rats during crystal meth addiction. JABS 2017; 7 (3) :377-389
URL: http://jabs.fums.ac.ir/article-1-1103-en.html
1- Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
2- Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran , homeirahatami@yahoo.com
Abstract:   (5880 Views)

Background & Objective: Crystal meth damages the brain cells by inducing oxidative stress. In the present study the long- term injection effect of alcoholic extract of Scrophularia Striata on spatial memory and lipid peroxidation in male rats during crystal meth addiction was investigated.
 Material & Methods: 49 male rats were divided in 7 groups including: control, sham (saline), crystal meth (5 mg/kg), Scrophularia Striata extract (100 and 200 mg/kg), pretreatment of Scrophularia Striata (100 mg/kg) + crystal meth (5 mg/kg), and pretreatment of Scrophularia Striata (200 mg/kg) + crystal meth (5 mg/kg).  Morris water maze test was used for assessing the spatial memory, and Malondialdehyde (MDA) was assayed as an index of lipid peroxidation. One-way analysis of variance (ANOVA) was used to analyze the data.
Results: Spatial memory was significantly reduced by Crystal meth (P<0.001). Spatial memory was significantly improved by Scrophularia (100 and 200 mg/kg) in comparison to control group (P<0.05). Pretreatment of Scrophularia in both doses significantly improved the spatial memory in crystal meth group (P<0.05). MDA level significantly increased in crystal meth group (P<0.05), but pretreatment of Scrophularia significantly reduced the elevated level of MDA (P<0.05).
Conclusion: It seems that, psychoactive drugs can impair spatial memory by inducing oxidative stress. Pretreatment of Scrophularia as an antioxidant, improves spatial memory which has been reduced by crystal meth.

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Type of Study: Research | Subject: Physiology
Received: 2016/08/5 | Accepted: 2017/04/18 | Published: 2017/11/15

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