Journal of Advanced Biomedical Sciences
JABS
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URL: http://jabs.fums.ac.ir/article-1-796-en.html
2- Department of Biology, Faculty of Basic Science Ilam University, Ilam, Iran
Background & Objective: Lichens are the result of the symbiosis of fungi and algae or a cyanobacterium. Various biological activities of some lichen and their components such as: antifungal, anti-bacterial, anti-tumor, anti-inflammatory, antiprotozoal substances are known. In the present study, antifungal activity of methanolic extract of Protoparmeliopsis muralis against Aspergillus flavus is investigated on rats.
Materials & Methods: 500 g of Protoparmeliopsis muralis was collected from KaneGonbad mountains in Ilam province, the methanol extract was prepared by soxhle. In order to determine the antifungal activity in in vivo conditions, a wound was created and infected with Aspergillus flavus. Having infected the wound, the researchers divided the rats into 4 subgroups: negative control group, treated with Kotrimoksazol, %5 ointment extract methanolic P. muralis, and with %10 ointment extract methanolic P. muralis. Treatment continued until complete healing of the wound. Finally, the percentage of wound healing was calculated.
Results: The result of the present study demonstrated that methanolic extract of P. muralis decreased the area of wound in the treatment group compared to the control group.
Conclusion: The antifungal and antioxidant activity of the extract of Protoparmeliopsis muralis accelerated the wound healing process.
Received: 2016/05/15 | Accepted: 2016/12/25 | Published: 2017/06/6
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)