en بررسی فعالیت ضد قارچی نانو کورکومین بر روی گونه های کاندیدا جدا شده از اتومیکوزیس قارچ شناسي Mycology پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#0070c0">Background & Objective: </span></span></span></b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Candida</span></span></i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> species are one of the most common causes of otomycosis. Antifungal drugs commonly used in treatment often have a variety of side effects, including toxicity, cross-reactivity, and drug resistance. In recent years, along with the advances in nanotechnology and the motivation to find new antifungal drugs, there has been a growing interest in the use of nanoparticles such as nano-curcumin in the treatment of fungal infections. The aim of this study was to evaluate the antifungal sensitivity of nano-curcumin on <i>Candida</i> species isolated from otomycosis.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#0070c0">Materials & Methods:</span></span></span></b>&nbsp; <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">In this experimental study, 100 isolated <i>Candida</i> samples from patients with otomycosis were included. Synthesis of nano-curcumin using chitosan (CS) nanoparticles was performed by ionic gelation method. Antifungal susceptibility testing was performed using broth microdilution method according to CLSI-M27-S4 guidelines on all <i>Candida</i> isolates to miconazole, clotrimazole and nanocurcumin. Data were analyzed in SPSS 27 software with </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">independent t-test </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">and </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">chi-squared </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">tests.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#0070c0">Results:</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Curcumin nanoparticles showed antifungal activity against all <i>Candida</i> species. However, the mean MIC of miconazole and clotrimazole for different <i>Candida</i> species was significantly lower than curcumin nanoparticles, indicating the lower antifungal effect of nano-curcumin than these two antifungals. Also, the mean MIC of nano-curcumin was not significantly different among <i>Candida</i> species (P < 0.05), whereas it was significantly different for miconazole and clotrimazole (P < 0.05).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#0070c0">Conclusion: </span></span></span></b>&nbsp;<span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The results of the present study showed that nano-curcumin had a lower antifungal effect than miconazole and clotrimazole, but due to nano-curcumin&#39;s safety, it can be used as a potential antifungal drug for the treatment of otomycosis after further investigation.</span></span></span></span></span></div> Candida, Otomycosis, Nanocurcumin, Miconazole, Clotrimazole 271 278 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3287-1&slc_lang=en&sid=1 Hossein Kashirifar حسین کشیری فر akbarhossiennejad@yahoo.com 100319475328460028151 100319475328460028151 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بابل، بابل، ایران Keyvan Kiakojouri کیوان کیاکجوری kia_ko13358@yahoo.com 100319475328460028152 100319475328460028152 Yes Department of Ear, Nose and Throat, School of Medicine, Roohani Hospital, Babol University of Medical Sciences, Babol, Iran گروه گوش، حلق و بینی، دانشکده پزشکی، بیمارستان روحانی، دانشگاه علوم پزشکی بابل، بابل، ایران Saeid Mahdavi Omran سعید مهدوی عمران mahdavios@yahoo.co.uk 100319475328460028153 100319475328460028153 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات بیماری‌های عفونی و گرمسیری، پژوهشکده بهداشت، دانشگاه علوم پزشکی بابل، بابل، ایران Akbar Hoseinnejad اکبر حسین نژاد akbarhosseinnejad@gmail.com 100319475328460028154 100319475328460028154 No Department of Medical Mycology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran. گروه قارچ شناسی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران. Jalal Jafarzadeh جلال جعفر زاده j.jafarzade1@gmail.com 100319475328460028155 100319475328460028155 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات بیماری‌های عفونی و گرمسیری، پژوهشکده بهداشت، دانشگاه علوم پزشکی بابل، بابل، ایران Ahmad Reza Aminian احمدرضا امینیان mojtabataghizade@yahoo.com 100319475328460028156 0009-0003-6006-5623 No Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران Mohammad Jahangiri محمد جهانگیری mohammad.jahangiri17@gmail.com 100319475328460028157 0009-0001-3137-8116 No Université de Lorraine, Inserm, Défaillance Cardiovasculaire Aigue et Chronique (DCAC), Université de Lorraine, Lorraine, France. دانشگاه لورن، اینسرم، نارسایی حاد و مزمن قلبی عروقی (DCAC)، دانشگاه لورن، لورن، فرانسه. Soghra Bagheri صغری باقری 100319475328460028158 100319475328460028158 No Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. گروه قارچ شناسی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران. Mojtaba Taghizadeh Armaki مجتبی تقی زاده ارمکی M.Taghizadeh@mubabol.ac.ir 100319475328460028159 100319475328460028159 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات بیماری‌های عفونی و گرمسیری، پژوهشکده بهداشت، دانشگاه علوم پزشکی بابل، بابل، ایران