en اثر عصاره ابی لاوندر بر مارکرهای استرس اکسیداتیو در نمونه های سرم و بافت پری فورنتال کورتکس راتهای القا شده با استرس مزمن خفیف بيوشيمي بالینی Biochemistry پژوهشي Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Background & Objective:</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Oxidative stress is associated with the pathology of various neuropsychiatric disorders, such as depression and anxiety. The aim of the study was to examine the impacts of the lavender aqueous extract (LAE) on the levels of oxidative stress markers <a name="_Hlk26135675">in an animal model with chronic mild stress induced depression.</a></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Materials & Methods: </span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">36 adult male Sprague&ndash;Dawley rats were haphazardly split into 6 groups (n=6). Rats in the test groups were put through five weeks of chronic mild stress. The sucrose preference test (SPT) confirmed depressive-like behaviors in the rats. Rats in both unstressed and stressed control groups received LAE (200 or 400 mg / kg) and distilled water respectively. The specific activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (Gpx), malondialdehyde (MDA) and as well as the total content of glutathione (GSH) were examined in the serum, liver and prefrontal cortex (PFC) using colorimetric assays. </span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Results:&nbsp; </span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The stress group experienced a significantly decreased level of GSH, SOD, GR, Gpx and CAT, and a statistically considerable augment in MDA level in in the serum, PFC and liver <i>p</i><0.05.&nbsp; LAE at both doses significantly reversed the depression-caused oxidative stress markers in all the studied tissues. No significant difference was observed between the two used dosages of LAE. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#2f5496">Conclusion: </span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">LAE is able to ameliorate depression-induced pathology possibly through anti-oxidant activity. </span></span></span></span></span></div> Chronic mild stress, Antioxidant activity, Lavender, Aqueous extract, Oxidative stress 288 301 http://jabs.fums.ac.ir/browse.php?a_code=A-10-3172-1&slc_lang=en&sid=1 Mir Behrad Aghazadeh Ghadim میر بهراد آقازاده قدیم 100319475328460028120 100319475328460028120 No Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران Amir Mahmoodzadeh امیر محمود زاده 100319475328460028121 100319475328460028121 No Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران Asma Neisy اسما نیسی 100319475328460028122 100319475328460028122 No Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران Zahra Khoshdel زهرا خوشدل khoshdelz@sums.ac.ir 100319475328460028123 100319475328460028123 Yes Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران