fa مقایسه سمیت اسانس میخک (Syzygium aromaticum) و ماده اصلی تشکیل‌دهنده آن (اوژنول) بر روی رده‌های سلولی سرطان پستان خاصیت ضد سرطانی اسانس میخک و اوژنول داروسازي و فارماکولوژِی Pharmacology پژوهشي Research <div style="text-align: justify;"><strong><em>Background & Objective:</em></strong> Breast cancer is the most common cancer among women, especially in developed countries. Because of resistance to chemotropic drugs, the development of new green drugs is crucial. Essential oils with a broad range of bioactivities such as antioxidant and anticancer activities are great resources for research and development. In this study, anticancer effects of clove (<em>Syzygium aromaticum</em>) essential oil as the common medicinal plant against some human breast cancer cell lines was investigated.<br> <strong><em>Materials & Methods:</em></strong> Components of clove essential oil were identified. The anticancer effect of the essential oil and its major ingredient (eugenol) was investigated on four human breast cancer cell lines.<br> <strong><em>Results:</em></strong> Ninety-two percent of clove essential oil was included by eugenol (65%), <em>trans</em>-caryophyllene (12%), eugenol acetate (10%), caryophyllene oxide (3%), and a-humulene (2%). Both clove essential oil and eugenol showed proper effect (IC₅₀ &micro;g.mL^-1) on targeted cell lines, MCF-7 (151.94 and 86.13), MDA-MB-175 (162.92 and 33.25), MDA-MB-231 (180.61 and 69.75), and MDA-MB-468 (211.11 and 53.91).<br> <strong><em>Conclusions:</em></strong> Regarding the proper anticancer effects of both samples, they could be considered as anticancer agents for further investigation.<br> &nbsp;<br> &nbsp;</div> Syzygium aromaticum, eugenol, anticancer effect 3028 3034 http://jabs.fums.ac.ir/browse.php?a_code=A-10-2124-1&slc_lang=fa&sid=1 Hiva Alipanah هیوا علی پناه alipanah.hiwa@yahoo.com 100319475328460024808 100319475328460024808 No Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Ali Ghanbariasad علی قنبری اسد alighanbariasad@gmail.com 100319475328460024809 100319475328460024809 No Department of Medical Biotechnology, Schools of Medicine, Fasa University of Medical Sciences, Fasa, Iran گروه بیوتکنولوژی پزشکی، دانشکده‌ پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران Mahmoud Osanloo محمود اوصانلو osanloo_mahmood@yahoo.com 100319475328460024810 100319475328460024810 Yes Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran مرکز تحقیقات بیماری‌های غیر واگیر، دانشگاه علوم پزشکی فسا، فسا، ایران