fa تهیه فیلم مخاط چسب دیفن هیدرامین هیدروکلراید و ارزیابی خصوصیات فارماسیوتیکس آن داروسازي و فارماکولوژِی Pharmacology پژوهشي Research <p><font face="Times New Roman" size="3">&nbsp;</font></p> <p class="MsoNormal" dir="rtl" style="margin: 0cm -3.55pt 10pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl mso-layout-grid-align: none"><b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">زمینه و هدف: </span></b><span lang="FA" style="font-family: ">فیلم‌های مخاط چسب جهت افزایش زیست دست یابی داروها و هم چنین راحتی بیمار طراحی شده‌اند. این مطالعه جهت طراحی فیلم دیفن هیدرامین هیدروکلراید و ارزشیابی خصوصیات فارماسیوتیکس آن صورت گرفته است.</span></p> <p class="MsoNormal" dir="rtl" style="margin: 0cm -3.55pt 10pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl mso-layout-grid-align: none"><b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">مواد و روش‌ها: </span></b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">در این مطالعه فیلم‌ها حاوی 10 میلی گرم دیفن هیدرامین هیدروکلراید</span><span lang="AR-SA" style="font-family: ">،<span style="background: rgb(250, 250, 250) color: black"><font face="B Nazanin" size="2"> به روش </font></span></span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">solvent-casting</span><span lang="FA" style="font-family: "> با استفاده از پلیمرهای </span><span dir="ltr" lang="FR" style="font-family: ">HPMC</span><span lang="AR-SA" style="font-family: ">، </span><span dir="ltr" lang="FR" style="font-family: ">PVA</span><span lang="AR-SA" style="font-family: ">، </span><span dir="ltr" lang="FR" style="font-family: ">NaCMC</span><span lang="FA" style="font-family: "> ساخته شده‌اند. فیلم‌ها از نظر یکنواختی</span><span lang="AR-SA" style="font-family: ">، ضخامت، وزن، درصد تورم پذیری، درصد آزادسازی دارو در محیط </span><span dir="ltr" lang="FR" style="font-family: ">in-vitro</span><span lang="AR-SA" style="font-family: ">، مقدار داروی موجود در فیلم و میزان کشش و درصد افزایش طول بررسی شدند.</span></p> <p class="MsoNormal" dir="rtl" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl mso-layout-grid-align: none"><b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">نتایج:</span></b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: "> ضخامت فیلم‌ها در محدوده 13/0 تا 25/0 میلی متر و وزن فیلم‌ها در محدوده 98/0 تا 26/1 میلی گرم می‌باشد. فیلم </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">F1</span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: "> </span><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">(حاوی</span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">875mg HPMC,125mg PVA</span><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">) و فیلم </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">F5</span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: "> </span><span lang="FA" style="background: rgb(250, 250, 250) color: black font-family: ">(حاوی </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">HPMC 50 mg,PVA 950 mg</span><span lang="FA" style="background: rgb(250, 250, 250) color: black font-family: ">) و فیلم </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">F6</span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: "> </span><span lang="FA" style="background: rgb(250, 250, 250) color: black font-family: ">(حاوی </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">800mg PVA</span><span lang="FA" style="background: rgb(250, 250, 250) color: black font-family: ">) تست‌های اولیه را با موفقیت گذراندند و هیچ گونه حباب یا چروکیدگی در آن‌ها مشاهده نشد. فیلم </span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">F1</span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: "> </span><span lang="FA" style="background: rgb(250, 250, 250) color: black font-family: ">8/97% از دارو را در 5 ساعت</span><span lang="AR-SA" style="font-family: ">، فیلم </span><span dir="ltr" lang="FR" style="font-family: ">F5</span><span lang="FR" style="font-family: "> </span><span lang="FA" style="font-family: ">7/96% از دارو را در 2 ساعت و فیلم </span><span dir="ltr" lang="FR" style="font-family: ">F6</span><span lang="FA" style="font-family: "> 6/97% دارو را در</span><span dir="ltr" lang="FA" style="font-family: "> </span><span lang="FA" style="font-family: ">40</span><span dir="ltr" lang="FA" style="font-family: "> </span><span lang="FA" style="font-family: ">دقیقه آزاد می‌کند.</span></p> <p><b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">نتیجه‌گیری:</span></b><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: "> فیلم </span><span dir="ltr" lang="FR" style="font-family: ">(F6)</span><span lang="FR" style="font-family: "> </span><span lang="AR-SA" style="background: rgb(250, 250, 250) color: black font-family: ">حاوی</span><span dir="ltr" lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">PVA </span><span lang="FR" style="font-family: "><span style="mso-spacerun: yes"><font face="B Nazanin" size="2">&nbsp;</font></span></span><span lang="FA" style="font-family: ">6/97% از دارو را در 40 دقیقه آزاد می‌کند. این فیلم خصوصیات فارماسیوتیکس مناسب جهت استفاده‌های درمانی را داراست.</span><font face="Times New Roman" size="3">&nbsp;</font></p> <p><b><i><span lang="FR" style="color: black font-family: ">Background </span></i></b><b><i><span dir="rtl" lang="AR-SA" style="color: black font-family: ">&</span></i></b><b><i><span lang="FR" style="color: black font-family: "> Objective:</span></i></b><b><span lang="FR" style="color: black font-family: ">&nbsp;</span></b><span lang="FR" style="color: black font-family: ">In recent years, mucoadhesive drug delivery systems has shown interested for prolonging the residence time of the dosage form and for providing a controlled rate of drug release. Mucoadhesive buccal films can enhance drug bioavailability by absorption through buccal mucosa and bypassing the first pass metabolism for improved therapeutic effect.. In addition, buccal films have advantages such as providing a convenient accessibility, painless method of drug delivery, and improved patient compliance. Buccal tablets allow drinking, eating, and speaking without any major discomfort.</span><font face="Times New Roman" size="3">&nbsp;</font><font face="Times New Roman" size="3">&nbsp;</font></p> <p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal mso-layout-grid-align: none"><b><i><span lang="FR" style="color: black font-family: ">Materials </span></i></b><b><i><span dir="rtl" lang="AR-SA" style="color: black font-family: ">&</span></i></b><b><i><span lang="FR" style="color: black font-family: "> Methods:</span></i></b><b><span lang="FR" style="color: black font-family: ">&nbsp;</span></b><span lang="FR" style="color: black font-family: ">Buccal films of diphenhydramine were prepared by solvent casting technique using Hydroxyl Propyl Methyl Cellulose (HPMC)<span dir="rtl"><font face="Times New Roman" size="2">&nbsp;</font></span>6000cps, Sodium Carboxymethyl Cellulose (NaCMC), and Poly Vinyl Alcohol (PVA). Prepared films were evaluated for weight, thickness, swelling index, drug content uniformity, tensile strength, and in vitro<i>&nbsp;</i>release studies.</span></p> <p><b><i><span lang="FR" style="color: black font-family: ">Results:</span></i></b><b><span lang="FR" style="color: black font-family: ">&nbsp;</span></b><span lang="FR" style="color: black font-family: ">The thickness of the films were between 0.13 and 0.25 mm. Their weight were in range of 0.98 and 1.26. F1 (containing </span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">875mg HPMC and 125mg PVA</span><span lang="FR" style="color: black font-family: ">), F5 (made of </span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">HPMC 50 mg and PVA 950mg</span><span lang="FR" style="color: black font-family: ">), and F6 (containing </span><span lang="FR" style="background: rgb(250, 250, 250) color: black font-family: ">800mg PVA</span><span lang="FR" style="color: black font-family: ">) showed success in the primary tests. No bubble or shrinkage was observed in them. F1, F5, and F6 released 97.8%, 96.7%, and 97.6% of the drug, respectively during five hours, two hours, and 40 minutes.&nbsp;</span><font face="Times New Roman" size="3">&nbsp;</font></p> <p class="MsoNormal" style="margin: 0cm 0cm 0pt text-align: justify line-height: normal mso-layout-grid-align: none"><b><i><span lang="FR" style="color: black font-family: ">Conclusion:</span></i></b><b><span lang="FR" style="color: black font-family: ">&nbsp;</span></b><span lang="FR" style="color: black font-family: ">F6, which contained 800mg PVA, released 97.6% of the drug in 40 minutes. This film has proper pharmaceutic characteristics to be used.</span></p> مخاط چسب, فیلم داروئی, دیفن هیدرامین, جذب دهانی Diphenhydramine, Mucoadhesive, Oral Films 14 22 http://jabs.fums.ac.ir/browse.php?a_code=A-10-234-1&slc_lang=fa&sid=1 Rahim Bahri Najafi رحیم بحری نجفی bahrir@pharm.mui.ac.ir 100319475328460011442 100319475328460011442 Yes Pharmaceutics Department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of medical Sciences, Iran. گروه فارماسیوتیکس، دانشکده داروسازی و علوم دارویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران. Dena Monzavi دنا منزوی dennnnaaa@yahoo.com 100319475328460011443 100319475328460011443 No Pharmaceutics Department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of medical Sciences, Iran. گروه فارماسیوتیکس، دانشکده داروسازی و علوم دارویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.