Journal of Advanced Biomedical Sciences

fa مطالعه هیستولوژیک و هیستومورفومتریک تاثیر عصاره آبی- الکلی گیاه صبرزرد بر ساختار بافتی عصب سیاتیک در موش‌های صحرایی نر بالغ دیابتی Histologic and Histomorphometric Study on the Effect of Hydro-Alcoholic Aloe Vera Extract on Tissue Formation of Sciatic Nerve in Diabetic Male Rats بافت شناسي Histology پژوهشي Research <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">زمینه و هدف:<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> دیابت ملیتوس باعث نقص متابولیسم کربوهیدرات‌ها، چربی‌ها و پرونئین‌ها شده که در نهایت منجر به عملکرد ناقص سیستم عصبی محیطی می‌شود.<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> تحقیقات<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نشان<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">داده‌اند<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">که<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">گیاه آلوئه ورا اثر<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">ضد<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دیابتی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دارد؛<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">لذا<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">در این پژوهش تاثیر عصاره آبی الکلی آلوئه ورا بر نوروپاتی دیابتی مورد مطالعه قرار گرفت.<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"><o:p /> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">مواد و روش‌ها<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">: 45 سر موش صحرایی نر در محدوده وزنی 250<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr">-<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">200 گرم در 3 گروه<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: X-NONE mso-fareast-language: X-NONE"> <span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: X-NONE mso-fareast-language: X-NONE">15 تایی <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">شامل: کنترل، نجربی 1(دیابتی+ غذای معمولی) و تجربی 2 (دیابتی+ عصاره آلوئه ورا) به طور تصادفی تقسیم بندی شدند. گروه‌های تجربی 2 و 1 با تزریق استرپتوزوتوسین به میزان <span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr">mg/kg<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> 50 دیابتی گردیدند. گروه‌های کنترل و تجربی 2، به مدت 12 و 16 هفته عصاره آلوئه ورا با دوز <span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> mg/kg<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">50 از طریق گاواژ دریافت نمودند. سپس عصب سیاتیک موش‌ها تشریح و خارج گردید. تغییرات ساختمانی عصب سیاتیک با مطالعات هیستولوژیک و هیستومورفومتریک مورد بررسی قرار گرفت. داده‌ها با استفاده از نرم افزار<span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> Spss <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">مورد تجزیه و تحلیل قرار گرفت.<o:p /> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نتایج:<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> در<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">حیوانات<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دیابتی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">کاهش<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">معنی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">داری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">در<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">میانگین<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">قطر<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">رشته‌های<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">عصبی میلین<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دار و ضخامت میلین<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">رشته‌های<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">عصبی مشاهده<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">شد.<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">درمان<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">طولانی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">مدت<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">با آلوئه ورا<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">به<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">طور<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">معنی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">داری<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">از<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">تمام<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">این<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">ناهنجاری‌ها<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">در<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">عصب سیاتیک حیوانات<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">دیابتی<span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">جلوگیری کرده بود. <span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Arial Unicode MS" mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: "B Nazanin"" dir="ltr"> <span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><o:p /><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نتیجه‌گیری:<span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-ansi-font-size: 8.0pt mso-ascii-font-family: "Times New Roman" mso-fareast-font-family: "Arial Unicode MS" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> یافته‌های ما نشان دادند که عصاره آبی الکلی آلوئه ورا به عنوان یک عامل با پتانسیل درمانی می‌تواند از تغییرات هیستومورفومتریک و هیستولوژیک ناشی از نوروپاتی محیطی دیابتی جلوگیری کند.<o:p /> Background & Objective: Diabetes mellitus affects the metabolism of carbohydrates, lipids, and proteins, which leads to the dysfunction of the central and peripheral nervous system. Reports suggest that Aloe Vera has anti-diabetic effects. Therefore, this study was carried out to determine the effect of hydro alcoholic extract of Aloe Vera on Sciatic nerve of the diabetic rats.Materials & Methods: 45 male Sprague-Dawley rats weighing 200-250 gram were randomly divided into three groups of 15 rats as control group, the experimental group1 (DM), and the experimental group 2(DM+ Aloe Vera). Diabetes in the experimental groups of one and two was induced by injection of 50mg/kg Streptozotcin. The control group and the experimental group two received 50mg/kg Aloe Vera by gavage for 12 and 16 weeks. Then, the animals were anesthetized and sciatic nerves were dissected and fixed. The tissue changes of the sciatic nerves were surveyed by histologic and histomorphometric studies. The data have been analyzed by using the SPSS software<o:p /> Results: In diabetic rats, a significant decrease was seen in the mean diameter of the myelinated nerve fibers and myelin sheath thickness of the Sciatic nerve. Long-term treatment with Aloe Vera significantly prevented all these abnormalities in treated diabetic rats (P <0/05).<o:p /> Conclusion: Our findings showed that the hydro alcoholic extract of Aloe Vera as a potential therapeutic agent that can help prevent histomorphometric and histologic changes induced by diabetic peripheral neuropathy.<o:p /> صبر زرد, نوروپاتی دیابتی, عصب سیاتیک, موش صحرایی Aloe Vera, Diabetic neuropathy, Sciatic nerve, Rat 409 417 http://jabs.fums.ac.ir/browse.php?a_code=A-10-194-2&slc_lang=fa&sid=1 Hamidreza Ghaffari حمیدرضا غفاری hamidghaffary@yahoo.com 0937787841 10031947532846006234 Yes Department of Anatomy, zabol University of Medical Sciences, Zabol, Iran. بخش آناتومی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران. Soghra Gholami صغری غلامی gholami@shirazu.ac.ir 1818746395 10031947532846006235 No Department of Anatomy, Shiraz University, Shiraz, Iran. بخش آناتومی، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران. Majid Naghdi مجید نقدی 10031947532846006236 10031947532846006236 No Department of Anatomy, Fasa University of Medical Sciences, Fasa, Iran. بخش آناتومی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران. Malihe Alipoor Tabrizi ملیحه علیپور تبریزی 10031947532846006237 10031947532846006237 No Department of Heart of Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. دپارتمان قلب بیمارستان امام رضا(ع)، دانشگاه علوم پزشکی مشهد، مشهد، ایران.